Patrick Waters PhD
Co-director of Autoimmune Neurology Diagnostic Laboratory, Oxford, UK
I completed my undergraduate studies in biochemistry at University College Cork (1994) and received a PhD on the structural prediction of the Fv region of a human IgG immunoglobulin from the University of East London (1999) under the guidance of Prof. Shawn Doonan. I pursued postdoctoral studies with Prof. Nick Willcox developing MHC Class II tetramers to identify specific CD4+ T cells in autoimmune myasthenia gravis and created fragments of surfactant proteins A, D and C1q as therapeutics in allergic asthma and invasive pulmonary aspergillosis with Dr. Uday Kishore.
Since 2007 I have worked in the identification of antibody targets in central nervous system diseases with Prof. Angela Vincent and more recently with Prof. Sarosh Irani. We identified CASPR2, LGI1, Glycine receptor and GABA-A receptor (g2 subunit) as antibody targets in CNS autoimmune diseases. I have collaborated on acute demyelinating lesional models for AQP4 and MOG.
I have developed numerous diagnostic tests for CNS autoimmunity and evaluated their use in multicentre studies and am now focussed on understanding the development of BCR autoreactivity that contributes to autoimmune disease.