SI is the leading the Neuroinflammation Unit at BRIC. She is trained biologist, performed her Dr. Med. Sci./PhD in the field of Experimental Neurology at Karolinska institute, Sweden and postdoctoral fellowship at Harvard Medical School, USA. She first established her own research team at Lund University, Sweden. Since 2007, she is a full professor at BRIC, University of Copenhagen. She is well known for her contribution in the field of cytokine regulation and the bi-directional communication between neurons and T lymphocytes in central nervous system (CNS). Her lab has been among the first to identify and describe immunological properties of neurons in the CNS and their impact on regulation of immune cells and brain inflammation. Additionally her lab has identified a new type of T regulatory cells (FoxA1+Treg cells) essential to limit neuroinflammation. The team also identified the first immune genes (IFN-beta and its receptor IFNAR), lack of which causes Parkinson’s-like pathology and dementia in mice. Her research team also established how these immune genes contribute to the regulation of autophagy/mitophagy, dysfunction of which leads to proteinopathies and neurodegenerative diseases.
She has served as scientific chair and advisor of several prestigious national and international research councils. She has been acting as an expert/advisor for National Institute of Health, USA. She is regularly acting as reviewer for high ranked, and prestigious journals.