Professor McCombe is a graduate of the Medical School of the University of Queensland. She trained in Neurology at Prince Henry/Prince of Wales Hospital in Sydney, and then obtained a PhD from the University of Sydney. This was the start of her interest in Neuroimmunology . She is now a Neurologist at Royal Brisbane and Women’s Hospital and Professor at the Faculty of Medicine at University of Queensland. Her research interests are broad, and encompass autoimmune diseases of the nervous system as well as immune response to acquired diseases of the brain. She has published on experimental autoimmune encephalomyelitis, multiple sclerosis, myasthenia gravis, Guillain Barre syndrome and CIDP, stroke and motor neurone disease. She has a special interest in the role of gender and of pregnancy in neurological and immune disease.