Day 2 | November 9

Event starts: 09/11/2021 10.00 GMT
Roland Liblau Congress Chair
Sonia Berrih-Aknin Congress Co-Chair
Amit Bar-Or ISNI President
Francisco Quintana ISNI President Elect
Chair: Samia Khoury (Lebanon) & David Laplaud (France)

I | Neuroimmunology of CNS demyelinating disorders

10:30 AM-11:00 AM: Functional involvement of the HLA-DR15 haplotype in the autoimmune pathogenesis of MS Roland Martin (University of Zurich, Switzerland)
11:00 AM-11:30 AM: The T cell-Phagocyte Interface in Neuroinflammation Burkhard Becher (University of Zurich, Switzerland)
11:30 AM-12:00 PM: Role of the inflammasome in MS Manuel Comabella (Vall d’Hebron University Hospital, Spain)
12:00 PM-12:15 PM BREAK
Chair: Pr Roopali

Sanofi | Targeting New Pathways in MS Pathophysiology

12:15 PM-1:00 PM: Professor Timothy Vartanian (Multiple Sclerosis Center, Weill Cornell Medicine, New York City, NY, USA)

1:00 PM-1:15 PM: Q/A
Moderator/Chair: Pr Hélène Zéphir (Neurologist Lille Hospital University - France)

12:15 PM-12:20 PM: Introduction Béatrice Baciotti (Medical Director Biogen France)
12:20 PM-12:40 PM: NAbs as potential therapeutic targets in MS Pr. Heinz Wiendl (Neurologist - Münster Hospital University - Germany)
12:40 PM-1:00 PM: New targets of research on Alzheimer's Diseases Thierry Bussière (Dementia Principal Investigator - Biogen)
Discussion & Q&A Chairs & Speakers
Conclusion & Key messages Chair
1:15 PM-1:30 PM BREAK
Chairs: Sonia Garel (France) & Jon Laman (Netherlands)

II | Brain-Immune system interactions in physiological conditions

1:30 PM-2:00 PM: Single-cell clonotype tracing of encephalitogenic T cells Vijay Kuchroo (Harvard Medical School and Brigham and Women’s Hospital, USA)
2:00 PM-2:30 PM: Anticipating pathogen invasion: Neuroimmune activation preserves gut homeostasis Gabrielle Belz (The University of Melbourne, Australia)
2:30 PM-3:00 PM: Dissecting functions of Microglia and non-parenchymal CNS macrophages Steffen Jung (The Weizmann Institute of Science, Israel)
3:00 PM-3:15 PM BREAK
LECTURE | 3:15 PM-4:15 PM GMT
Chair: Amit Bar-Or (USA)

The Newsom-Davis Lecture

Immune mechanisms in neurologic disease Howard Weiner (Harvard University, Brigham and Women’s Hospital, USA)
4:15 PM-4:30 PM BREAK
Chair: Tanja Kuhlmann (Germany) & Ari Waisman (Germany)

I | Dialog between astrocytes and microglia in neuroimmunology

4:30 PM-4:55 PM: Microglia in early brain wiring: from circuit assembly to tissue integrity Sonia Garel (Université Paris, France)
4:55 PM-5:10 PM: 59-Astrocyte-Oligodendrocyte interaction drives central nervous system remyelination Irene Molina Gonzalez University of Eidenburgh, UK)
5:10 PM-5:35 PM: Regulation of CNS Macrophages in Health and Disease Melanie Greter (University of Zurich, Switzerland)
5:35 PM-5:50 PM: 249-APOE4 impairs microglia response to neurodegeneration in Alzheimer's Disease Neta Rosenzweig (Brigham and Women's Hospital, Harvard Medical School, USA)
5:50 PM-6:15 PM: Astrocyte heterogeneity in Multiple Sclerosis Francisco Quintana (Harvard Medical School, Brigham and Women’s Hospital, USA)
6:15 PM-6:30 PM: 308-Selective inhibition of soluble TNF promotes beneficial neuroinflammatory responses and remyelination in the cortical grey matter Athena Boutou (Hellenic Pasteur Institute, Greece)
Chairs: Sylviane Pied (France) & Nicolas Blanchard (France)

II | Parasites and neuroinflammation

4:30 PM-4:55 PM: A conserved GABAergic system in mononuclear phagocytes -implications for Toxoplasma infection Antonio Barragan (Stockholm University, Sweden)
4:55 PM-5:10 PM: 246-Studying the mechanisms of neuroinflammation-induced cognitive alterations associated with Toxoplasma gondii infection Marcy Belloy (University of Toulouse, France)
5:10 PM-5:35 PM: CD4 and CD8 T cells infiltrate the brain and form brain-resident memory after blood-stage infection with P. berghei ANKA William Heath (University of Melbourne, Australia)
5:35 PM-5:50 PM: 108-Regional cyst localisation and innate immune activation of the retina and brain in murine toxoplasmosis Dana Lee (Queensland University of Technology, Australia)
5:50 PM-6:15 PM: Mechanisms of fatal blood barrier dysfunction during cerebral malaria Dorian McGavern (NINDS, USA)
Chairs: Laurent Groc (France) & Jerome Honnorat (France)

III | Antibody-mediated diseases: new targets and new mechanisms

4:30 PM-4:55 PM: The different syndromes and mechanisms of neuronal synaptic autoantibodies Josep Dalmau (University of Barcelona, Spain)
4:55 PM-5:10 PM: 191-Immunogenetics in autoimmune encephalitis and related disorders Sergio Muniz-Castrillo (Hospices Civils de Lyon, Hôpital Neurologique, France)
5:10 PM-5:35 PM: The peculiar features of IgG4 and its role in autoimmune diseases Maartje Huijbers (Leiden University Medical Center, Netherlands)
5:35 PM-5:50 PM: 259-The role of SWAP-70 and FCRL2 in pathophysiology of multiple sclerosis and their value as biomarker Elif Sanli (Istanbul University, Turkey)
5:50 PM-6:15 PM: Autoimmune encephalitis and epilepsy Maarten Titulaer (Erasmus MC University Medical Center, Netherlands)
6:15 PM-6:30 PM: 131-Clinical and laboratory features in anti-NF155 autoimmune nodopathy Lorena Martin-Aguilar (University of Vienna, Austria)
6:30 PM-6:45 PM BREAK
Chairs: Bente Finsen (Denmark) & Stephane Hunot (France)

I | Innate and Adaptive Immunity in AD, Parkinson and ALS

6:45 PM-7:15 PM: Lymphocyte trafficking to the CNS – does provenance matter? Thomas Korn (Klinikum rechts der Isar, Technische Universität München, Germany)
7:15 PM-7:30 PM: 57-CYP46A1 in the choroid plexus: an unexpected safeguard of brain function lost in Alzheimer’s disease Afroditi Tsitsou-Kampeli (Weizmann Institute of Science, Israel)
7:30 PM-7:45 PM: 34-Effects of IgLON5 antibodies on neuronal cytoskeleton: A link between autoimmunity and neurodegeneration Jon Landa (University de Barcelona, Spain)
7:45 PM-8:00 PM: 55-Etiology-independent disease-associated oligodendrocytes in CNS pathologies Mor Kenigsbuch (Weizmann Institute of Science, Israel)
8:00 PM-8:15 PM: 287-Disrupting the neuroimmune crosstalk in the spleen exacerbates cognitive loss in animal model of Alzheimer’s disease Tommaso Croese (Weizmann Institute of Science, Israel)
8:15 PM-8:30 PM: 38-Repurposing the anxiolytic drug buspirone to counteract inflammation in cellular and animal models of Parkinson’s disease Sarah Thomas Broome (University of Technology Sydney, Australia)
Chairs: Sandra Amor (Netherlands) & Lennart Mars (France)

II | Modeling neuroinflammation using IPSC, organoids and animal models

6:45 PM-7:15 PM: Th17 lymphocyte-induced neuronal cell death in Parkinson’s disease Iryna Prots (University Hospital Erlangen, Germany)
7:15 PM-7:30 PM: 375-Human induced pluripotent stem cells-derived neurons to study CNS-reactive autoantibodies in COVID-19-mediated neurological syndromes Amandine Mathias (Lausanne University Hospital and Lausanne University, Switzerland)
7:30 PM-7:45 PM: 336-Mapping of radiation-induced microglia activation in whole-brain mouse histological images Sindi Nexhipi (National Center for Radiation Research in Oncology, Germany)
7:45 PM-8:00 PM: 185-Intrinsic regulation of Th17 cell pathogenicity by IL-24 Christopher Sie (Technical University of Munich, Germany)
8:00 PM-8:15 PM: 90-Decline of Neural Stem Cell Resilience in Multiple Sclerosis Alexandra M. Nicaise (University of Cambridge, UK)
8:15 PM-8:30 PM: 184-Regulatory B cells required IL-2 signaling to control disease severity in EAE Juliette Gauthier (University of Rennes, France)
8:30 PM-8:45 PM: 356-Using hiPSC-derived CNS cells as antigen presenting cells for unbiased identification of CNS-autoreactive CD8+ T cells Sylvain Perriot (Lausanne University Hospital, Switzerland)
Chair: Rejane Rua (France) & Simon Fillatreau (France)

III | Single cell analyses in neuroimmunology: essential or overrated?

6:45 PM-7:15 PM: Oligodendroglia cell states in multiple sclerosis: insights from single-cell transcriptomics and epigenomics Gonçalo Castelo-Branco (Karolinska Institutet, Sweden)
7:15 PM-7:30 PM: 304-Single cell analysis reveals incomplete tolerance mechanisms in MOGAD patients Alicia Zou (University of Sydney, Australia)
7:30 PM-7:45 PM: 298-Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology Amy Smith (University of Auckland, New Zealand)
7:45 PM-8:00 PM: 363-Single-cell transcriptome profiling revealed the distinct transcriptional response of microglia-like cells during herpes simplex encephalitis Olus Uyar (Université Laval, Canada)
8:00 PM-8:15 PM: 54-Exploring reported genes of microglia RNA-seq studies: uses and considerations Techla van Wageningen (Amsterdam UMC, the Netherlands)
8:15 PM-8:30 PM: 200-CXCR4-positive T cells are increased in people with radiologically isolated syndrome Raphael Schneider (Keenan Research Center for Biomedical Science, Canada)
8:30 PM-8:45 PM: 225-CanProCo study; Determining technical parameters for large scale single-cell RNA sequencing of MS patients Fiona Tea (L'Universitè de Montréal, Canada)
Chairs: Violetta Zujovic (France) & Abdelhadi Saoudi (France)

IV | Immunomodulation and remyelination

6:45 PM-7:15 PM: Promoting macrophage/microglia activity for remyelination V. Wee Yong (University of Calgary, Canada)
7:15 PM-7:30 PM: 187-TNFR2 regulates the response of oligodendrocyte precursor cells to neuroinflammation Haritha Desu (University of Miami, USA)
7:30 PM-7:45 PM: 17-Targeting lipophagy in macrophages improves repair in multiple sclerosis Melanie Loix (Hasselt University, Belgium)
7:45 PM-8:00 PM: 61-Exogenous fractalkine enhances oligodendrogenesis and remyelination in the cuprizone-induced demyelination mouse model Monique Marylin Alves de Almeida (University of Alberta, Canada)
8:00 PM-8:15 PM: 123-Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain Jeroen F.J. Bogie (Hasselt University, Belgium)
8:15 PM-8:30 PM: 220-Themis1/Vav1 signaling hub controls T cell pathogenicity in a mouse model of Multiple Sclerosis Rémi Marrocco (INFINITY, France)
8:30 PM-8:45 PM: 65-Elevated expression levels of Ephrins on Immune Cells of Patients With Multiple Sclerosis Affects Oligodendrocyte Differentiation Maya Golan (Tel Aviv Sourasky Medical Center, Israel)