Day 3 | November 10

Event starts: 10/11/2021 10.30 GMT
POSTER SESSION (10:30 AM-12:30 PM GMT)
12:30 PM-12:45 PM BREAK
INDUSTRY SYMPOSIUM (12:45 PM-1:45 PM GMT)
CELGENE/BMS
1:45 PM-2:00 PM BREAK
PLENARY SESSION (2:00 PM-3:30 PM GMT)
Chairs: Shohreh Issazadeh-Navikas (Denmark) & Guillaume Dorothée (France)

III | Neuroimmunology of neurodegenerative diseases and ageing
2:00 PM-2:30 PM: TBC
2:30 PM-3:00 PM: Systemic blockade of anti-PD-l1 can potentially overcome Trem2 polymorphism in combating Alzheimer’s disease Michal Schwartz (Weizmann Institute of Science, Israel)
3:00 PM-3:30 PM: Marco Colonna (Washington University School of Medicine St. Louis, USA)
3:30 PM-3:45 PM BREAK
PARALLEL SYMPOSIA (3:45 PM-5:45 PM GMT)
Chairs: Catharina C. Gross (Germany) & Julie Ribot (Portugal)


IV | Barriers of the CNS: actors in neuroinflammation
3:45 PM-4:10 PM: Regulation of the blood-brain barrier in health and disease Richard Daneman (University of California, San Diego, USA)
4:10 PM-4:25 PM: Oral Presentation
4:25 PM-4:50 PM: Modelling T-cell autoimmunity of the CNS grey and white matter Francesca Odoardi (University Medical Center Göttingen, Germany)
4:50 PM-5:05 PM: 157-Immune protection at the CNS borders: heterogeneity and maturation of meningeal macrophages Elisa Eme-Scolan (Immunology Center of Marseille-Luminy, France)
5:05 PM-5:30 PM: Unbiased and large-scale CNS endothelium transcriptomic analyses in human and mouse Alexandre Prat (CHUM, Université de Montréal, Canada)
5:30 PM-5:45 PM: Oral presentation
Chair: Patrick Vermersch (France)


V | Autoimmune neurological disorders (other than MS)
3:45 PM-4:10 PM: Neuromyelitis optica spectrum disorders: Pathobiology predicts treatment response for AQP4-IgG-associated subtype Brian Weinshenker (Mayo Clinic, USA)
4:10 PM-4:25 PM: Oral Presentation
4:25 PM-4:50 PM: Brain control of adaptive immunity Hai Qi (HHMI International Research Scholar, China)
4:50 PM-5:05 PM: Oral presentation
5:05 PM-5:30 PM: New aspects of autoimmune neuromuscular junction disorders Angela Vincent (the University of Oxford, USA)
5:30 PM-5:45 PM: Oral presentation
Chairs: Daniel Gonzalez-Dunia (France) & Trevor Owens (Denmark)

VI | Viruses and neuroinflammation
3:45 PM-4:10 PM: Innate immune mechanisms of pathological forgetting Robyn Klein (Washington University School of Medicine – St. Louis, USA)
4:10 PM-4:25 PM: 127-MAVS is required to mount IFN-β- and broad innate immune responses in VSV infected microglia Olivia Luise Gern (Hannover Medical School and the Helmhotz Center for INfection Research, Germany)
4:25 PM-4:50 PM: Epstein-Barr virus and multiple sclerosis: from autoimmunity to virus-induced immunopathology? Francesca Aloisi (Istituto Superiore di Sanità, Italy)
4:50 PM-5:05 PM: 156-Age-dependent meningeal macrophages protect against viral neuroinfection Rejane Rua (Immunology Center of Marseille-Luminy, France)
5:05 PM-5:30 PM: Disentangling pathological and protective T cell responses in the CNS Doron Merkler (Centre Médical Universitaire, Switzerland)
5:30 PM-5:45 PM: Oral presentation
5:45 PM-6:00 PM BREAK
LECTURE (6:00 PM-7:00 PM GMT)
Chair: Gianvito Martino (Italy)

The Immunology Lecture
6:00 PM-7:00 PM: Unraveling the Complex Pathogenesis of Multiple Sclerosis Using Animal Models Joan Goverman (University of Washington, USA)
7:00 PM-7:15 PM BREAK
WORKSHOP (7:15 PM-9:15 PM GMT)
Chairs: Caroline Pot (Switzerland) & Guy Gorochov (France)

V | Does our food affect our brain via the immune system?
7:15 PM-7:45 PM: Diet and the gut microbiome shape the course
of multiple sclerosis
Aiden Haghikia (Ruhr-Universität Bochum, Germany)
7:45 PM-8:00 PM: Oral Presentation
8:00 PM-8:15 PM: 56-Sialic acid-driven untimely immune aging in obesity-Alzheimer’s disease comorbidity accelerates cognitive decline Stefano Suzzi (the Weizmann Institute of Science, Israel)
8:15 PM-8:30 PM: Oral Presentation
8:30 PM-8:45 PM: Oral Presentation
8:45 PM-9:00 PM: 115-Dietary supplementation with conjugated linoleic acid ameliorates intestinal inflammation and CNS autoimmunity Ann-Katrin Fleck (University of Münster, Germany)
9:00 PM-9:15 PM: Oral Presentation
Chair: Serge Nataf (France)

VI | Brain ageing: impact of immunity and infection
7:15 PM-7:45 PM: Uncovering immune responses driving cellular communities towards proteinopathy and cognitive decline in 1.6 million individual transcriptomes Philip De Jager (Columbia University, USA)
7:45 PM-8:00 PM: 110-Aging perturbs microglia function and upregulates osteopontin to accelerate oxidized phosphatidylcholine-mediated neurodegeneration Jeff Dong (University of Calgary, Canada)
8:00 PM-8:15 PM: Oral Presentation
8:15 PM-8:30 PM: Oral Presentation
8:30 PM-8:45 PM: Oral Presentation
8:45 PM-9:00 PM: Oral Presentation
9:00 PM-9:15 PM: Oral Presentation
Chairs: Sylvain Fisson (France) & Cécile Delarasse (France)

VII | Neuroimmunology of the eye and the optic nerve
7:15 PM-7:45 PM: Microbiota and the eye – is there a gut-eye axis? Rachel Caspi (National Eye Institute, NIH, USA)
7:45 PM-8:00 PM: Oral Presentation
8:00 PM-8:15 PM: 254-The early emergence of aquaporin 4-specific B cells characterises neuromyelitis optica spectrum disorders Sudarshini Ramanathan (John Radcliffe Hospital; University of Oxford, Oxford, UK/ University of Sydney; Kids Neuroscience Centre, Children’s Hospital at Westmead, Australia/ Concord Hospital, Australia)
8:15 PM-8:30 PM: Oral Presentation
8:30 PM-8:45 PM: Oral Presentation
8:45 PM-9:00 PM: 377-Subretinal Associated Immune Inhibition, a new antigen-specific immunosuppressive mechanism in the context of AAV gene transfer Sylvain Fisson (Université Paris Saclay)
9:00 PM-9:15 PM: 162-Role of P2X7 receptor in mouse experimental autoimmune uveitis (EAU) Cécile Delarasse (Institut de la Vision, France)
Chair: Sophie Laffont (France)

VIII | Sex, chromosomes, and hormones in neuroimmunology
7:15 PM-7:45 PM: Sex Chromosome Effects on Autoimmunity Rhonda Voskuhl (UCLA Multiple Sclerosis Program, USA)
7:45 PM-8:00 PM: 276-In utero exposure to maternal Anti-Caspr2 antibodies alters microglial activation and development in male offspring Ben Spielman (The Feinstein Institutes for Medical Research)
8:00 PM-8:15 PM: 67-Suppression of the disease-relevant brain-homing T cell in MS by nuclear receptor crosstalk Steven C. Koetzier (Erasmus MC, University Medical Center)
8:15 PM-8:30 PM: Oral Presentation
8:30 PM-8:45 PM: Oral Presentation
8:45 PM-9:00 PM: 133-CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism and cognitive decline Hugo Peluffo (UDELAR, Institut Pasteur de Montevideo, Uruguay)
9:00 PM-9:15 PM: Oral Presentation