Day 3 | November 10

Event starts: 10/11/2021 10.30 GMT
12:30 PM-12:45 PM BREAK
Chair: Pr Roland Liblau (Toulouse, France)

BMS | S1P receptor from Central nervous system to clinical use

12:45 PM-1:00 PM: Lymphocyte dynamics in the central nervous system during health and in Multiple Sclerosis Pr Britta Engelhardt (Bern Switzerland)
1:00 PM-1:15 PM: Role of S1P receptors and CNS migration cells Pr Jack Antel (Montreal, Canada)
1:15 PM-1:30 PM: Targeting and involvement of S1PR modulators in Multiple Sclerosis and other pathologies Pr Jeffrey A. Cohen (Cleveland, USA)
1:30 PM-1:45 PM: Questions and conclusion Pr Roland Liblau and all
1:45 PM-2:00 PM BREAK
Chairs: Shohreh Issazadeh-Navikas (Denmark) & Guillaume Dorothée (France)

III | Neuroimmunology of neurodegenerative diseases and ageing
2:00 PM-2:30 PM: Etiopathogenic relevance of CD8 T cells in Parkinson’s disease: inferences from a postmortem study Jordi Bové (Vall d'Hebron Research Institute (VHIR), Spain)
2:30 PM-3:00 PM: Systemic blockade of anti-PD-l1 can potentially overcome Trem2 polymorphism in combating Alzheimer’s disease Michal Schwartz (Weizmann Institute of Science, Israel)
3:00 PM-3:30 PM: TBD Marco Colonna (Washington University School of Medicine St. Louis, USA)
3:30 PM-3:45 PM BREAK
Chairs: Catharina C. Gross (Germany) & Julie Ribot (Portugal)

IV | Barriers of the CNS: actors in neuroinflammation
3:45 PM-4:10 PM: Regulation of the blood-brain barrier in health and disease Richard Daneman (University of California, San Diego, USA)
4:10 PM-4:25 PM: 282-DICAM Promotes TH17 Lymphocyte Trafficking Across the Blood-Brain Barrier during Neuroinflammation Marc Charabati (CRCHUM, Université de Montréal, Montreal, Canada)
4:25 PM-4:50 PM: Modelling T-cell autoimmunity of the CNS grey and white matter Francesca Odoardi (University Medical Center Göttingen, Germany)
4:50 PM-5:05 PM: 157-Immune protection at the CNS borders: heterogeneity and maturation of meningeal macrophages Elisa Eme-Scolan (Immunology Center of Marseille-Luminy, France)
5:05 PM-5:30 PM: Unbiased and large-scale CNS endothelium transcriptomic analyses in human and mouse Alexandre Prat (CHUM, Université de Montréal, Canada)
5:30 PM-5:45 PM: 85-Oncostatin M opens the gate for T helper 17 cells during neuroinflammation Doryssa Hermans (Hasselt University, Diepenbeek, Belgium)
Chair: Patrick Vermersch (France) & Anne-Katrin Pröbstel (Switzerland)

V | Autoimmune neurological disorders (other than MS)
3:45 PM-4:10 PM: Neuromyelitis optica spectrum disorders: Pathobiology predicts treatment response for AQP4-IgG-associated subtype Brian Weinshenker (Mayo Clinic, USA)
4:10 PM-4:25 PM: 71-T cell-mediated neuronal destruction in GAD65-Encephalitis calls for early immunosupressive treatment Anna Troscher (Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna, Austria)
4:25 PM-4:50 PM: Brain control of adaptive immunity Hai Qi (HHMI International Research Scholar, China)
4:50 PM-5:05 PM: 255Prospective long-term tocilizumab responses in relapsing myelin oligodendrocyte glycoprotein IgG-associated disease: factors associated with post-tocilizumab relapse-freedom Fan Cheng (Department of Neurology, Hull Royal Infirmary, Hull University Hospitals NHS Trust, Kingston upon Hull, United Kingdom)
5:05 PM-5:30 PM: New aspects of autoimmune neuromuscular junction disorders Angela Vincent (the University of Oxford, USA)
5:30 PM-5:45 PM: 281-Investigating anti-inflammatory and immunomodulatory properties of brivaracetam in experimental autoimmune encephalomyelitis (EAE) Oumarou Ouédraogo (University of Montreal, CHUM research Center, Montréal, Canada)
Chairs: Daniel Gonzalez-Dunia (France) & Trevor Owens (Denmark)

VI | Viruses and neuroinflammation
3:45 PM-4:10 PM: Innate immune mechanisms of pathological forgetting Robyn Klein (Washington University School of Medicine – St. Louis, USA)
4:10 PM-4:25 PM: 127-MAVS is required to mount IFN-β- and broad innate immune responses in VSV infected microglia Olivia Luise Gern (Hannover Medical School and the Helmhotz Center for INfection Research, Germany)
4:25 PM-4:50 PM: Epstein-Barr virus and multiple sclerosis: from autoimmunity to virus-induced immunopathology? Francesca Aloisi (Istituto Superiore di Sanità, Italy)
4:50 PM-5:05 PM: 156-Age-dependent meningeal macrophages protect against viral neuroinfection Rejane Rua (Immunology Center of Marseille-Luminy, France)
5:05 PM-5:30 PM: Disentangling pathological and protective T cell responses in the CNS Doron Merkler (Centre Médical Universitaire, Switzerland)
5:30 PM-5:45 PM: 52-Human iPSC-derived astrocytes as a model to understand JCV infection in the brain Larise Oberholster (Lausanne University Hospital (CHUV), Lausanne, Switzerland)
5:45 PM-6:00 PM BREAK
LECTURE (6:00 PM-7:00 PM GMT)
Chair: Gianvito Martino (Italy)

The Immunology Lecture
6:00 PM-7:00 PM: Unraveling the Complex Pathogenesis of Multiple Sclerosis Using Animal Models Joan Goverman (University of Washington, USA)
7:00 PM-7:15 PM BREAK
WORKSHOP (7:15 PM-9:15 PM GMT)
Chairs: Caroline Pot (Switzerland) & Guy Gorochov (France)

V | Does our food affect our brain via the immune system?
7:15 PM-7:45 PM: Diet and the gut microbiome shape the course
of multiple sclerosis
Aiden Haghikia (Ruhr-Universität Bochum, Germany)
7:45 PM-8:00 PM: 62-Diet-dependent regulation of TGFb impairs reparative innate immune responses after demyelination Mar Bosch Queralt (Paul Flechsig Institute for Neuropathology, Germany)
8:00 PM-8:15 PM: 56-Sialic acid-driven untimely immune aging in obesity-Alzheimer’s disease comorbidity accelerates cognitive decline Stefano Suzzi (the Weizmann Institute of Science, Israel)
8:15 PM-8:30 PM: 140-Neurological alterations and intestinal dysbiosis associated with subclinical food allergy Kumi Nagamoto-Combs (University of North Dakota, USA)
8:30 PM-8:45 PM: 171-Impact of methionine intake on neuroinflammatory processes in a spontaneous sex-biased animal model of multiple sclerosis Victoria Hannah Mamane (Canada)
8:45 PM-9:00 PM: 115-Dietary supplementation with conjugated linoleic acid ameliorates intestinal inflammation and CNS autoimmunity Ann-Katrin Fleck (University of Münster, Germany)
9:00 PM-9:15 PM: 289-Impact of high fibre diet and its combination with intermittent fasting in CNS autoimmunity Eileen Liao (The University of Sydney, Australia)
Chair: Serge Nataf (France) & Elsa Suberbielle (France)

VI | Brain ageing: impact of immunity and infection
7:15 PM-7:45 PM: Uncovering immune responses driving cellular communities towards proteinopathy and cognitive decline in 1.6 million individual transcriptomes Philip De Jager (Columbia University, USA)
7:45 PM-8:00 PM: 110-Aging perturbs microglia function and upregulates osteopontin to accelerate oxidized phosphatidylcholine-mediated neurodegeneration Jeff Dong (University of Calgary, Canada)
8:00 PM-8:15 PM: 136-Aging blood factors promote CD8 T cell infiltration in the adult mouse brain Lynn Van Olst (Amsterdam UMC, Utrecht)
8:15 PM-8:30 PM: 342-Deranged granulopoiesis drives poor outcome of ischemic stroke in the elderly Giorgia Serena Gullotta (Università Vita-Salute San Raffaele, Milano)
8:30 PM-8:45 PM: 328-Aged CNS-resident cells promote a non-remitting course of experimental autoimmune encephalomyelitis Jeffrey Atkinson (The Ohio State University, USA)
8:45 PM-9:00 PM: 267-Ageing promotes non-remitting experimental autoimmune encephalomyelitis with persistent meningeal inflammation and subpial demyelination in SJL/J mice Michelle Zuo (University of Toronto, Canada)
9:00 PM-9:15 PM: 307-Chronic demyelination-induced cell senescence is associated with motor impairment in a model of MS Irini Papazian (Hellenic Pasteur Instιtute, Greece)
Chairs: Sylvain Fisson (France) & Cécile Delarasse (France)

VII | Neuroimmunology of the eye and the optic nerve
7:15 PM-7:45 PM: Microbiota and the eye – is there a gut-eye axis? Rachel Caspi (National Eye Institute, NIH, USA)
7:45 PM-8:00 PM: 202-Is it the Vaccine? Case Reports and Systematic Review of Postvaccination Neuromyelitis Optica Spectrum Disorder Nanthaya Tisavipat (Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok)
8:00 PM-8:15 PM: 254-The early emergence of aquaporin 4-specific B cells characterises neuromyelitis optica spectrum disorders Sudarshini Ramanathan (John Radcliffe Hospital; University of Oxford, Oxford, UK/ University of Sydney; Kids Neuroscience Centre, Children’s Hospital at Westmead, Australia/ Concord Hospital, Australia)
8:15 PM-8:30 PM: 201-Aberrant DNA methylation of Runx1 promotes Th17 induced autoimmunity in  Neuromyelitis Optica Spectrum Disorders Yuhan Qiu (China)
8:30 PM-8:45 PM: 73-SATP mediates neuropathic pain in neuromyelitis optica via microglial activation Ishikura Teruyuki (Osaka University, Japan)
8:45 PM-9:00 PM: 377-Subretinal Associated Immune Inhibition, a new antigen-specific immunosuppressive mechanism in the context of AAV gene transfer Sylvain Fisson (Université Paris Saclay)
9:00 PM-9:15 PM: 162-Role of P2X7 receptor in mouse experimental autoimmune uveitis (EAU) Cécile Delarasse (Institut de la Vision, France)
Chair: Sophie Laffont (France) & Nathalie Arbour (Canada)

VIII | Sex, chromosomes, and hormones in neuroimmunology
7:15 PM-7:45 PM: Sex Chromosome Effects on Autoimmunity Rhonda Voskuhl (UCLA Multiple Sclerosis Program, USA)
7:45 PM-8:00 PM: 276-In utero exposure to maternal Anti-Caspr2 antibodies alters microglial activation and development in male offspring Ben Spielman (The Feinstein Institutes for Medical Research)
8:00 PM-8:15 PM: 67-Suppression of the disease-relevant brain-homing T cell in MS by nuclear receptor crosstalk Steven C. Koetzier (Erasmus MC, University Medical Center)
8:15 PM-8:30 PM: 116-Regulatory T cells contribute to sexual dimorphism in neonatal hypoxic-ischemic brain injury Josephine Herz (Department of Pediatrics I, University Hospital Essen)
8:30 PM-8:45 PM: 264-Antidiabetic and antiaging role of Moringa oleifera  on hippocampus of experimental male rats Pardeep Kumar (Jawaharlal Nehru University, Delhi)
8:45 PM-9:00 PM: 133-CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism and cognitive decline Hugo Peluffo (UDELAR, Institut Pasteur de Montevideo, Uruguay)