Day 5 | November 12

Event starts: 12/11/2021 10.30 GMT
WORKSHOP (10:30 AM - 12:30 PM GMT)
Chairs: Roland Liblau (France) & Miyake Sachiko (Japan)

XIII | Immunoregulation of neuroinflammation
10:30AM-11:00AM: Myositoxicity: a dark side of The Checkpoint Immunotherapy Revolution Yves Allenbach (Pitié Salpetriere University Hospital, France)
11:00AM-11:15AM: 365-MCAM involvement in regulatory T cell migration across the blood brain barrier: implications for multiple sclerosis Stephanie Zandee (CRCHUM, UdeM, Canada)
11:15AM-11:30AM: 96-Investigation of the opsonizing capacity of patient-derived anti-MOG antibodies Marie Freier (IDepartment of Neuropathology, University Medical Center Göttingen, Germany)
11:30AM-11:45AM: 297-Flanking residues of a self-dominant peptide harnesses immunity via determining the stability of antigen-specific effector Tregs Youwei Lin (National Institute of Neuroscience and National Center Hospital,  National Center of Neurology and Psychiatry, Japan)
11:45AM-12:00AM: 315-Impaired Treg suppressive function in MS is correlated with an age- and treatment-dependent altered Treg dynamics Tiziana Lorenzini (Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, Switzerland)
12:00PM-12:15PM: 348-Selective deletion of IDO1+ cDC1 worsened CNS inflammation in an experimental model of multiple sclerosis Giulia Scalisi (Univeristy of Perugia, Italy)
12:15PM-12:30PM: 229-Regulatory B cells ameliorate chronic CNS inflammation in an interleukin-10-dependent manner Silke Häusser-Kinzel (University Medical Center Göttingen, Germany)
Chair: Melanie Greter (Switzerland) & Trevor Owens (Denmark)

XIV | Diversity of brain myeloid cells
10:30AM-11:00AM: Heterogeneity of myeloid cells in the CNS Marco Prinz (University Hospital Freiburg, Germany)
11:00AM-11:15AM: 16-Migration and functional polarization of monocyte derived cells across the central nervous system barriers during neuroinflammation Daniel C. Ivan (Theodor Kocher Institut, University of Bern, Bern, Switzerland)
11:15AM-11:30AM: 274-Oxysterol-production by brain endothelial cells suppresses Myeloid-Derived Suppressor Cells and promotes experimental autoimmune encephalomyelitis Florian Ruiz (Lausanne University Hospital, Switzerland)
11:30AM-11:45AM: 116-Regulatory T cells contribute to sexual dimorphism in neonatal hypoxic-ischemic brain injury Josephine Herz (Department of Pediatrics I, University Hospital Essen, Germanu)
11:45AM-12:00AM: 237-Microglia heterogeneity in different regions of the healthy mouse central nervous system Fazeleh Etebar (Queensland University of Technology, Australia)
12:00PM-12:15PM: 350-IL-15 expression is distinctly modulated on myeloid cells by inflammatory factors in MS Negar Farzam-kia (University of Montreal, CRCHUM, Canada)
12:15PM-12:30PM: 147-Exploring the transcriptomic diversity of live human microglia in aging, neurodegeneration, and neuroinflammation John Tuddenham (Columbia University, USA)
Chair: Anne Dejean (France) & Benoit Salomon (France)

XV | Metabolism in Neuroimmunology
10:30AM-11:00AM: Targeting the metabolism of T cells for the treatment of autoimmune disease Luciana Berod (University Medical Center of the Johannes Gutenberg University Mainz, Germany)
11:00AM-11:15AM: 10-Multiple Sclerosis iPSC-derived astrocytes show disease-related alterations in mitochondrial dynamics, inflammatory response and metabolism Bruno Ghirotto (University of São Paulo, Brazil)
11:15AM-11:30AM: 24-Dissecting the role of IGF1R in neuroinflammation: a parallel focus on oligodendrocytes and myeloid cells Giuseppe Locatelli (Theodor Kocher Institute, University Bern, Switzerland)
11:30AM-11:45AM: 182-Regulation of human oligodendrocytes process extension by the integrated stress response Florian Pernin (McGill University, Canada)
11:45AM-12:00AM: 233-Eomes regulates mitochondrial function and promotes survival of pathogenic CD4+ T cells during CNS autoimmunity Emeline Joulia (INFINITY, Toulouse, France)
12:00PM-12:15PM: 68-Alterations in adipokine levels in MS patient cohort project Y Merel Rijnsburger (Amsterdam UMC, Netherlands)
12:15PM-12:30PM: 146-Metabolic regulation of MS specific neural stem cells Rosana-Bristena Ionescu (Universiry of Cambridge, UK)
Chairs: Hans Lassmann (Austria) & Doron Merkler (Switzerland)

XVI | Tissue-resident T cells in CNS inflammation
10:30AM-11:00AM: Tissue resident memory T cells in multiple sclerosis Joost Smolder (University Medical Center Rotterdam, Netherlands)
11:00 AM-11:15AM: 18-CD8 T cells target enteric neurons in patients with gastrointestinal dysmotility Anna Brunn (Department of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany)
11:15AM-11:30AM: 215-Tissue-resident memory CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons David Frieser (INSERM, Toulouse, France)
11:30AM-11:45AM: 309-Regulatory T cells counteract CNS neuroinflammation via TGF-β signalling in CNS myeloid cells Stefan Bittner (University Medical Center Mainz, Mainz, Germany)
11:45AM-12:00PM: 319-Cytotoxic-like Eomes+ Th cells in secondary progressive multiple sclerosis Ben Raveney (National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan)
12:00PM-12:15PM: 117-Activated Eomes-Tfh1 cells infiltrate the cerebrospinal fluid in early Multiple Sclerosis Marion Mandon (CHU Pontchaillou, RENNES, France)
12:15PM-12:30PM: 292-Contact-dependent granzyme B-mediated cytotoxicity of Th17 cells towards human oligodendrocytes Hélène Jamann (CRCHUM, Montréal, Canada)
12:30PM - 12:40PM BREAK
Panel Discussion(12:40PM - 13:44PM GMT)
Chairs: Giancarlo Comi (Italy) & Roland Liblau (France)

Panel Discussion | Immunotherapy in MS: 8 key questions
12:40 PM-12:48 PM: MS one or several diseases?Catherine Lubetzki (Sorbonne University, France)
12:48 PM-12:56 PM: Is anti MOG a disease or one of the many variants of MS? Kazuo Fujihara (Southern TOHOKU Research Institute for Neuroscience, Japan)
12:56 PM-1:04 PM: Is MRI sensitive enough to detect inflammatory activity?Heinz Wiendl (University of Münster, Germany)
1:04 PM-1:12 PM: Is there any useful serum or CSF biomarker to detect and predict inflammatory activity? Hans-Peter Hartung (Department of Neurology Heinrich-Heine-Universität Düsseldorf, Germany)
1:12 PM-1:20 PM: Immunotherapy of MS: induction or escalation? Gilles Edan (University Hospital of Rennes, France)
1:20 PM-1:28 PM: Is there a role for cellular therapy? Frauke Zipp (University Mainz, Germany)
1:28 PM-1:36 PM: Can we fully block neuroinflammation in MS? Howard Weiner (Harvard University Brigham and Women's Hospital, USA)
1:36 PM-1:44 PM: Which combination immunotherapy can we forsee for MS? Patrick Vermersch (University Hospital of Lille, France)

1:45PM - 2:00PM BREAK
LECTURE (2:00PM - 3:00PM GMT)
Chair: Tomas Olsson (Sweden)

The Dale McFarlin Lecture
Translational reserach towards personalized medicine for MS and NMOSD Takashi Yamamura (National Institute of Neuroscience, NCNP, Japan)
3:00PM - 3:15PM BREAK
PARALLEL SYMPOSIA (3:15PM - 5:30PM GMT)
Chairs: Alexandre Prat (Canada) & Gabriela Constantin (Italy)

X | Drainage and immunosurveillance of the CNS
3:15PM-3:30PM 153-Pericytes play a protective role during neuroinflammation Dila Atak (Koç University, Turkey)
3:30PM-3:55PM Breaking (Bad) Brain Barriers Beliefs Jonathan Kipnis (Washington University in St. Louis, School of Medicine, USA)
3:55PM-4:10PM 169-The role of the meningeal layers in CNS autoimmunity Arianna Merlini (Institute for Neuroimmunology & Multiple Sclerosis Research (IMSF), Germany)
4:10PM-4:35PM Harnessing brain T cells to modulate neurodegeneration Adrian Liston (CHU PURPAN, France)
4:35PM-4:50PM 322-Migration across the blood-brain barrier affects mTOR signalling in regulatory T cells Paulien Baeten (BIOMED - Hasselt University, Belgium)
4:50PM-5:15PM Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for CNS inflammatory demyelination Abdolohamad Rostami (Thomas Jefferson University, USA)
5:15PM-5:30PM 166-Multiple sclerosis and circadian rhythm: a systematic review Francisco Lima-Neto (Universidade Estadual de Montes Claros)
Chairs: Naomi Habib (Israel) & Burkhard Becher (Switzerland)

XI | Multi-omics in Neuroimmunology
3:15PM-3:30PM 82-Transcriptome guided optimization of in vitro culture conditions for adult primary microglia Raissa Timmerman (BPRC, Netherlands)
3:30PM-3:55PM Single Cell Analysis of T cells in the CNS David Hafler (Yale School of Medicine, USA)
3:55PM-4:10PM 262-Investigating B cells and their depletion in relapsing-remitting Multiple Sclerosis using DNA methylation patterns Ewoud Ewing (Karolinska Institutet, Sweden)
4:10PM-4:35PM Integrating genome, metagenome and data science to understand MS Sergio Baranzini (University of California San Francisco, USA)
4:35PM-4:50PM 326-Transcriptomic characterization of CSF reveals T and Myeloid cells as early players during MS disease onset Hanane Touil (Columbia University, USA)
4:50PM-5:15PM Applied epigenomics: insights into the pathogenesis of Multiple Sclerosis Maja Jagodic (Karolinska Institutet, Sweden)
5:15PM-5:30PM 368-Large-scale phosphoproteomic mapping of RTKs reveals dynamic architecture and microglia expression in blunt TBI Rida Rehman (Ulm university, Germany)
Chairs: Roberto Furlan (Italy) Luc Vallières (Canada)

XII | Immunopsychiatry: is it a nascent field?
3:15PM-3:40PM Towards a clinical immunological diagnosis of psychiatric disorders Hemmo A. Drexhage (University Medical Center Rotterdam, the Netherlands)
3:40PM-3:55PM 33-Encephalitis with Autoantibodies against the Glutamate Kainate Receptor (GluK2) Jon Landa (IDIBAPS, Spain)
3:55PM-4:20PM Modulatory roles of the immune system in shaping animal behaviors Jun Huh (Harvard Medical School, USA)
4:20PM-4:35PM 80-Deviated B cell receptor repertoire in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Wakiro Sato (Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan)
4:35PM-5:00PM Remembering immunity: brain representation of peripheral immune activity Asya Rolls (Technion, Israel Institute of Technology, Israel)
5:00PM-5:15PM 279-Slow disease progression and clinical heterogeneity make anti-CASPR2 encephalitis a diagnostic challenge Jeanne Benoit (CHU de NICE,France)
5:30PM - 5:45PM BREAK
We are Neuroimmunology (5:45PM - 6:30PM GMT)
We are Neuroimmunology

Mid-Career Award
5:45PM-6:00PM Introduction
6:00PM-6:15PM Award 1
6:15PM-6:30PM Award 2
Closing Remarks (6:30PM - 7:00PM GMT)