Prof. Steffen Jung PhD
The Henry H. Drake Professioral Chair of Immunology
The Weizmann Institute of Science
Rehovot | Israel
Born in Homburg/ Saar, Germany, Steffen Jung began with his undergraduate studies at the University of Bonn, and then moved to the Institute of Genetics in Cologne. He performed his Ph.D. in the Department of Immunology headed by Klaus Rajewsky under the guidance of Andreas Radbruch. Specifically, he used the then newly developed gene targeting approach to define cis-acting control elements driving non-coding ‘sterile’ transcripts in immunoglobulin class switch recombination. In 1993, Steffen Jung moved for post-doctoral training to Israel and joined the laboratory of Yinon Ben-Neriah at the Lautenberg Center (Hebrew University, Jerusalem) studying transcription factors and kinases in T cell signaling. In 1997, Steffen Jung went to New York for a post-doc in the laboratory of Dan Littman at the Skirball Institute for Molecular Pathogenesis, NYU Medical Center. His studies there focused on the chemokine receptor CX3CR1 and its membrane-tethered ligand CX3CL1/ fractalkine. He generated CX3CR1gfp reporter mice that have become instrumental to define murine monocyte subsets and study brain microglia. Furthermore, he developed in collaboration with Richard Lang at the Skirball Institute a novel diphtheria toxin receptor (DTR)-based cell ablation strategy and a mouse model that allowed the study of dendritic cells (DC) in their in vivo context (CD11c-DTR mice). In 2002, Steffen Jung returned to Israel and joined the faculty of the Department of Immunology at the Weizmann Institute, where he received tenure in 2009 and full professorship in 2015. Current work of the Jung lab aims at elucidating in vivo aspects of mononuclear phagocytes, including the definition of developmental pathways and differential functions of monocytes, DC and macrophages. Specifically, the team applies intra-vital imaging, conditional cell and gene ablation and precursor graft-mediated reconstitution, combined with advanced genomic analysis to investigate the biology of these cells in physiological health and disease context. Recent work of the Jung laboratory focused on the study of monocyte-derived intestinal macrophages, yolk sac-derived brain microglia and lymph node DC, as well as the role of macrophages in brown fat and metabolic disorders.