Prof. Catherine Lubetzki MD, PhD
Fédération des maladies du système nerveux
et INSERM 711
Hôpital de la Salpêtrière
Paris, France

Catherine Lubetzki is professor of Neurology at Sorbonne University and medical director of Paris Brain Institute. She is vice president of Sorbonne University foundation.

She is involved in several committees and funding boards, among these the scientific committee of ARSEP (French Multiple Sclerosis association for research), the International Progressive MS Alliance Scientific Steering Committee.

Her clinical activity is mainly dedicated to the management of Multiple Sclerosis patients, and she coordinates the very active Paris-Salpêtrière Multiple Sclerosis center.

She is col-eading with Pr Bruno Stankoff a research group in Paris Brain Institute and a particular focus on axon-glia interactions in the central nervous system, during demyelination and remyelination, notably on the role of electrical activity

The general aim of her research group  is to develop strategies to promote repair, prevent neurodegeneration and reduce disability progression in Multiple Sclerosis patients.

Selected recent publications

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing-remitting multiple sclerosis.  Louapre C, Rosenzwajg M, Golse M, Roux A, Pitoiset F, Adda L, Tchitchek N, Papeix C, Maillart E, Ungureanu A, Charbonnier-Beaupel F, Galanaud D, Corvol JC, Vicaut E, Lubetzki C, Klatzmann D. J Neurol. 2023 May 28. doi: 10.1007/s00415-023-11690-6.

Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies.  Henriet E, Martin EM, Jubin P, Langui D, Mannioui A, Stankoff B, Lubetzki C, Khakhalin A, Zalc B.Brain. 2023 Jun 1;146(6):2453-2463.

Oligodendrocyte progenitor cell recruitment and remyelination in multiple sclerosis: the more, the merrier?  Tepavčević V, Lubetzki C. Brain. 2022 Sep 12:awac307. doi: 10.1093/brain/awac307

Genetically-modified macrophages accelerate myelin repair. Aigrot MS, Barthelemy C, Moyon C, Dufayet-Chaffaud G, Izagirre-Urizar L, Gillet-Legrand B,  Bayón-Cordero L, Tada S, Chara JC, Matute C, Cartier N^, Lubetzki C ^, and Tepavčević  V^ EMBO Mol Med. 2022 Aug 8;14(8):e14759. doi: 10.15252/emmm.202114759

Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination.  Ronzano R, Roux T, Thetiot M, Aigrot MS, Richard L, Lejeune FX, Mazuir E, Vallat JM, Lubetzki C*, Desmazières A*. Nat Commun. 2021 Sep 1;12(1):5219

Lubetzki C,  Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet neurology 2020, Aug;19(8):678-688. doi: 10.1016/S1474-4422(20)30140-X.

Lubetzki C, Sol-Foulon N and Desmazieres A Nodes of Ranvier during development and repair in the CNS? Nature review neurology, 2020 Aug;16(8):426-439. doi: 10.1038/s41582-020-0375-x.