Prof. Caroline Pot MD
Service of Neurology
Department of Clinical Neurosciences
Lausanne University Hospital
Lausanne | Switzerland
Caroline Pot is a clinician-scientist specialized in neuroimmunology with a strong expertise multiple sclerosis (MS). She was trained as a neurologist at the Geneva, Switzerland. In parallel to her clinical expertise, she completed her MD-thesis at the University of Zurich in Switzerland and performed a research fellowship at Harvard Medical School in Boston, USA. In 2015, she joined the Department of Clinical Neurosciences at the Lausanne University Hospital, awarded by a Swiss National Science Foundation Professorship and was nominated associate Professor in 2019.
Caroline Pot, together with her team, focuses her research on establishing the role of lipid metabolism and mucosal immunology in driving MS. They study the role of the cholesterol metabolites, oxysterols and showed that in addition to their contributions to basic metabolic processes, oxysterols are linked to inflammatory processes. More specifically oxysterols produced during experimental autoimmune encephalomyelitis (EAE) are important in recruiting encephalitogenic T lymphocytes and dampening anti-inflammatory immune responses. In addition they showed that the gut is an important reservoir for immune cells that are recruited in the intestine before migrating to the central nervous system.