Day 4 | August 23

ISNI DAY 3 - TUESDAY AUGUST 22

PLENARY SESSION


8:00am - 10:00am
Pathological mechanisms in autoimmune diseases of the nervous system
Chairs: Christopher Power (Canada) & Thomas Korn (Germany)

8:00am-8:30am | EBV-Mediated Molecular Mimicry in Multiple Sclerosis
William H. Robison (USA)

8:30am-9:00am | B cells, BAFF and CNS inflammation
Jen Gommerman (Canada)

9:00am-9:30am | Antibody Defined CNS Autoimmune Neurological Disorders: Discovery to Near Cure
Sean Pittock (USA)

9:30am-10:00am | New insights into how brain and periphery communicate
Jonathan Kipnis (USA)
Coffee Break | 10:00am-10:30am

MORNING BREAKOUT SESSIONS


10:30am - 12:00pm
Involvement of glial cells in neuroinflammation
Chairs: Nathalie Arbour (Canada) & Michael Simons (Germany)

10:30am-10:48am | Regulatory glial cell-cell interactions
Francisco Quintana (USA)

10:48am-11:06am | Insights from a unique model to study de novo myelination
Zhigang He (USA)

11:06am-11:24am | What is the role of reactive astrocytes in disease?
Shane Liddelow (USA)

Oral Presentations
11:24am-11:42am | #116 Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis
Cameron S. McAlpine (USA)

11:42am-12:00pm | #9 Fibulin-2 impedes oligodendrogenesis through engaging the Notch signaling pathway
Samira Ghorbani (Canada)		Influence of sex on neuroinflammation
Chairs: Lisa Osborne (Canada) & Ari Waisman (Germany)

10:30am-10:48am | Sex differences in microglial metabolism and implications for neural development
Staci Bilbo (USA)

10:48am-11:06am | Female sex exacerbates age-related changes in microglia
Marina Lynch (Ireland)

11:06am-11:24am | Adiposity interacts with female sex to promote T helper 1 inflammation and autoimmunity
Shannon Dunn (Canada)

11:24am-11:42am | Biological sex as a determinant in inflammatory T cell responses in chronic CNS autoimmunity
Manu Rangachari (Canada)

Oral Presentations
11:42am-12:00pm | #305 Role of sex, gonadal hormones and dutasteride treatment on central and peripheral inflammation in a mouse model of Parkinson’s disease.
Amandine Isenbrandt (Canada)
Lunch Break | 12:00pm-1pm

AFTERNOON BREAKOUT SESSIONS


1:00pm - 3:00pm
Microglia in neural development, remodelling, and protection
Chairs: Staci Bilbo (USA) & David Gosselin (Canada)

1:00pm-1:15pm | Diverse macrophages sense and govern brain environment
Takahiro Masuda (Japan)

1:15pm-1:30pm | The many roles of microglia in the pathogenesis of neurodegeneration
Rosa Paolicelli (Switzerland)

1:30pm-1:45pm | Roles of dark microglia during normal brain development
Marie-Eve Tremblay (Canada)

1:45pm-2:00pm | Microglia are required for remyelination
Jason Plemel (Canada)

Oral Presentations
2:00pm-2:15pm | #289 Avb8-Tgfb1 signaling in brain vascular and microglial development
Gabriel L. McKinsey (USA)

2:15pm-2:30pm | #128 Stearoyl-CoA desaturase-1 impairs the regenerative and anti-inflammatory properties of microglia and T cells in the brain
Jeroen F.J. Bogie (Belgium)

2:30pm-2:45pm | #17 APOE4 Impairs Microglia Response to Neurodegeneration in Alzheimer’s Disease
Neta Rosenzweig (USA)

2:45pm-3:00pm | #83 Microglia coordinate cellular interactions during spinal cord repair in mice
Faith H. Brennan (Canada)		T cells in neurological diseases
Chairs: Shannon Dunn (Canada) & Manu Rangachari (Canada)

1:00pm-1:15pm | Stranger Things about IL-12 and IL-23
Burkhard Becher (Switzerland)

1:15pm-1:30pm | Th17 cells- to be, or not be, is the question before us
Vijay Kuchroo (USA)

1:30pm-1:45pm | IL-17 controls CNS autoimmunity through the intestinal microbiome
Ari Waisman (Germany)

Oral Presentations
1:45pm-2:00pm | #11 TCF1 is a determinant of homeostatic versus pathogenic Th17 cell state
Ana C. Anderson (USA)

2:00pm-2:15pm | #193 Tissue-resident memory T cells sustain the chronic phase of experimental autoimmune encephalomyelitis
Frederick Masson (France)

2:15pm-2:30pm | #16 Brain endothelial antigen presentation detains CD8 T cells at the blood-brain barrier and contributes to its breakdown
Javier Pareja (Switzerland)

2:30pm-2:45pm | #355 Impaired CNS Immunosurveillance by CCR7+ CD4 T cells during chronic neuroinflammation
Elizaldi Sonny (USA)

2:45pm-3:00pm | #102 The transcription factor c-Maf promotes immunoregulation of CD8+ T cells in multiple sclerosis
Norio Chihara (Japan)		Biomarkers of neuroinflammation
Chairs: Catherine Larochelle (Canada) & Martina Absinta (Italy)

1:00pm-1:15pm | Compartment specific (endo)phenotyping of neuroinflammation
Heinz Wiendl (Germany)

1:15pm-1:30pm | Biomarkers of relapsing course in MOG antibody-associated disease
Fabienne Brilot (Australia)

1:30pm-1:45pm | What Information Does the Serum Biomarker Neurofilament Light Chain Offer in the Management of Multiple Sclerosis?
Mark Freedman (Canada)

Oral Presentations
1:45pm-2:00pm | #59 CanProCo Study; Examining Prognostic Protein Biomarkers in Sera and Plasma from Multiple Sclerosis Patients
Fiona Tea (Canada)

2:00pm-2:15pm | #286 Machine learning identifies a combination of immunological and clinical parameters as the best predictor of MS disease progression
Stephanie Zandee (Canada)

2:15pm-2:30pm | #266 Biomarkers in autoimmune diseases of the central nervous system : the autoimmune encephalitis challenge
Chloe Bost (France)

2:30pm-2:45pm | #310 Interleukin-7 receptor alpha is increased on CD4+ effector T cells in clinically established multiple sclerosis
Raphael Schneider (Canada)

2:45pm-3:00pm | #319 Immunosenescence trajectories in diverse human populations: evaluation of immune age towards personalized therapies
Hanane Touil (USA)		Learning about neuroimmunology through Parkinson's disease - Sponsored by ASAP
Chairs: John Lukens (USA) & Michael Heneka (Germany)

1:00pm-1:24pm | Parkinson’s Disease-proteins regulate the transition from innate to adaptive immunity
Michel Desjardins (Canada)

1:24pm-1:48pm | Innate Immune Dysfunction in People with Parkinson’s and Pre-clinical Models of disease
Malu Tansey (USA)

1:48pm-2:12pm | Unveiling the Enigma: Exploring Neuroinflammation's Impact on Parkinson's Disease
Ted Dawson (USA)

2:12pm-2:36pm | Microglia iron overload and ferroptosis cause neurodegeneration
Timothy Hammond (USA)

2:36pm-3:00pm | Brain-to-gut trafficking of alpha-Synuclein by CD11c+ macrophages in Parkinson’s Disease
Rhonda McFleder (Germany)

ISNI KEYNOTE LECTURE


3:15pm - 4:15pm
The Rita Levi-Montalcini Neurobiology Lecture
Chair: Alexandre Prat (Canada)

Inflammation and Neurodegeneration in multiple sclerosis: A single and common pathway?
Hans Lassmann (Austria)

POSTER SESSION 2


4:15pm - 6:15pm

Biomarkers of neuroinflammation
Influence of sex on neuroinflammation
Involvement of glial cells in neuroinflammation
Microglia in neural development, remodelling, and protection
Neuroimmunology general I
T cells in Neurological diseases

ISNI GENERAL ASSEMBLY


6:15pm - 7:15pm